Evening primrose oil (EPO) contains an omega-6 essential fatty acid, called gamma-linolenic acid (GLA), which is believed to be EPO’s active ingredient, which may contribute to the proper functioning of human tissues because they are precursors of anti-inflammatory eicosanoids. Primrose seeds also contain proteins, carbohydrates, minerals, and vitamins. EPO supplementation results in an increase in plasma levels of γ-linolenic acid and its metabolite dihomo-γ-linolenic acid (DGLA). This compound is oxidized by lipoxygenase (15-LOX) to 15-hydroxyeicosatrienoic acid (15-HETrE) or, under the influence of cyclooxygenase (COX), DGLA is metabolized to series 1 prostaglandins. These compounds have anti-inflammatory and anti-proliferative properties
- Minimize Mastalgia
- Induces Labor
- Shorten labor
- Improves Fertility
- Reduce menopausal symptoms Such as hot flashes
- Treating premenstrual syndrome (PMS)
- Prevent late deliveries in pregnant women
- Helps Manage Osteoporosis
- Improve overall skin health
- Nourishes Nails & Lightens Dark Spots
- For PMS (Pre menstrual symptoms) 1 to 2 gm BID for 3 to 6 cycles.
- For Mastalgia (breast pain) 1 GM BID for 2 to 6 months.
The essential fatty acids found in evening primrose oil are involved in the biosynthesis of prostaglandin. For this activity, the main involved component is the Gamolenic acid. The presence of this essential fatty acid allows the synthesis of anti-inflammatory substances such as 15-hydroxy-eicosatrienoic acid and prostaglandin
Imroza 500 affects the fatty acid composition of serum lipids and adipose tissue as well as it helps maintain normal cellular structures and it serves as a prostaglandin precursor.
Absorption When orally administered, the tmax was directly dependent to the time of administration, being of 2.7 hours in the evening and 4.4 hours in the morning. The Cmax and AUC were registered to be approximately 21 mcg/ml and 274 mcg.h/ml
Metabolism The main component of evening primrose oil, Alpha-Linolenic Acid is usually desaturated by delta-6-desaturase which transforms this fatty acid to Gamolenic acid. Gamolenic acid forms Dihomo-gamma-linolenic acid by the action of elongases and it can further act as a substrate for production of prostaglandins or to be denaturated to arachidonic acid.
Elimination The major components of the primrose oil are highly metabolized and the majority of the generated metabolites are excreted in the urine.
- Anticoagulants and anti-platelet drugs