Calmacit contains Calcium citrate, Cholecalciferol and folic acid.
Calcium citrate malate is the water soluble calcium supplement. It is the calcium salt of citric salt of citric acid and malic acid. It is supposed to have high bioavailability.
Cholecalciferol is one of the five forms of vitamin D. It is steroid molecule with one open ring and is also called as secosteroid. It is inactive and converted to active form by two hydroxylations by liver and kidney.
Folic acid is a vitamin B. It is often used in food industry. The term folate refers to the deprotonated ion and folic acid to the neutral molecule, which both co-exist in water.
- Preventing calcium deficiency
- Dietary supplement
- Produces minerals contained in bone
- As an antacid is effective for treating indigestion
- Calcitriol promotes absorption
- Vitamin D is made by body when body is exposed to sunlight
- Prevents osteoporosis
- Treats low level of calcium and phosphate
- Allows normal bone growth
One tablet twice daily for 3-6 months
Calcium citrate malate
It is the water soluble calcium supplement. It is the calcium salt of citric salt of citric acid and malic acid. It is supposed to have high bioavailability.
It requires activation by 25-hydroxylation in liver. The enzyme 27-hydroxylase catalyses oxidation of side chain of sterol intermediates. This active form binds to the intracellular receptors and function as transcription factor to cause gene modulation. Vitamin D receptors forms complex with other intracellular receptors. It increases the serum concentration by increasing the absorption. It also causes increase in osteoclastic reabsorption and increases distal renal tubular reabsorption of calcium. It is absorbed through formation of calcium binding protein.
Calcium citrate malate
After administration the drug is absorbed by small intestine in presence of bile salt.
Nearly about 99.8% of the drug is bound to plasma protein.
The elimination half life of drug is 19-48hrs.
After oral administration readily absorbed by the body
Nearly about 50-80% of the drug is bound to plasma protein. The metabolism of the drug is by liver.
- Patients with hypercalcemia or evidence of vitamin D toxicity
- Any of the inactive ingredient in the preparation is contraindicated
- Hypersensitivity to any ingredient
- High level of phosphate in blood
- Occlusion of artery
- Kidney diseases
- Excessive amount of vitamin D in body
- Excessive dosage causes hypercalcemia and in some instances hypercalciuria
- Patient should have normal renal function
- Adequate fluid intake
- Avoid non prescription drugs
- Regular analysis of the patients with such prescription.
- Patient with any allergic reactions
- Inactive ingredients can cause reactions
- High calcium or vitamin D levels