Calmacit-k2 2023-02-11T09:08:44+00:00

Calcium citrate malate –1000 mg
Calcitriol – 0.25 mcg
Vitamin K2 7 – 45 mcg
Zinc – 7.5 mg
Boron – 0.5 mg

Calmacit-K2 Tablets is a combination of Calcium citrate malate, Calcitriol, Vitamin K27, Zinc and Boron.


The medical information on this website is provided as an information resource only. The information on this website is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider or a medical practitioner in understanding any information or in applying information that you might have come across, on this website. Please note that it dangerous to take any medication without doctor’s prescription or professional advice from a registered health practitioner. Do not use this information in place of a visit, consultation or advice of your healthcare providers.

  • It helps in maintaining bone mineral density
  • Prevents calcium plaques forming in arteries of patients with osteoporosis
  • Osteoporosis
  • Parathyroidism
  • Osteomalacia
  • Prevents corticosteroid induced osteoporosis

One tablet once or twice daily.

Calcium citrate malate
It is the water soluble calcium supplement. It is the calcium salt of citric salt of citric acid and malic acid. It is supposed to have high bioavailability.

It requires activation by 25-hydroxylation in liver. The enzyme 27-hydroxylase catalyses oxidation of side chain of sterol intermediates. This active form binds to the intracellular receptors and function as transcription factor to cause gene modulation. Vitamin D receptors forms complex with other intracellular receptors. It increases the serum concentration by increasing the absorption. It also causes increase in osteoclastic reabsorption and increases distal renal tubular reabsorption of calcium. It is absorbed through formation of calcium binding protein.

Vitamin K27
It produces its actions by forming bones by acting on bone matrix proteins.

Calcium citrate malate

After administration the drug is absorbed by small intestine in presence of bile salt.

Nearly about 99.8% of the drug is bound to plasma protein.

The elimination half life of drug is 19-48hrs.


It is rapidly absorbed by the intestine with peak serum concentration achieving in 3-6hrs. The serum levels steady state is reaching in 7days with multiple dose administration.

Nearly about 99.9% of the drug is bound to blood. The drug is transported to the blood by alpha-globulin vitamin D binding protein. It involves two pathways for its metabolism i.e 24-hydroxylase catabolism of calcitriol and the second is conversion of calcitriol by stepwise hydroxylation.

The drug follows biliary excretion and excreted in feces.

  • Patients with hypercalcemia or evidence of vitamin D toxicity
  • Any of the inactive ingredient in the preparation is contraindicated
  • Hypersensitivity to any ingredient
  • Excessive dosage causes hypercalcemia and in some instances hypercalciuria
  • Patient should have normal renal function
  • Adequate fluid intake
  • Avoid non prescription drugs
  • Regular analysis of the patients with such prescription.
Send Enquiry

We are glad that you preferred to contact us. Please fill our short form and one of our friendly team members will contact you back.

    Send Enquiry