Calcium citrate malate –1000 mg
Calcitriol – 0.25 mcg
Vitamin K2 7 – 45 mcg
Zinc – 7.5 mg
Boron – 0.5 mg
Calmacit-K2 Tablets is a combination of Calcium citrate malate, Calcitriol, Vitamin K27, Zinc and Boron.
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- It helps in maintaining bone mineral density
- Prevents calcium plaques forming in arteries of patients with osteoporosis
- Prevents corticosteroid induced osteoporosis
One tablet once or twice daily.
It is the water soluble calcium supplement. It is the calcium salt of citric salt of citric acid and malic acid. It is supposed to have high bioavailability.
It requires activation by 25-hydroxylation in liver. The enzyme 27-hydroxylase catalyses oxidation of side chain of sterol intermediates. This active form binds to the intracellular receptors and function as transcription factor to cause gene modulation. Vitamin D receptors forms complex with other intracellular receptors. It increases the serum concentration by increasing the absorption. It also causes increase in osteoclastic reabsorption and increases distal renal tubular reabsorption of calcium. It is absorbed through formation of calcium binding protein.
It produces its actions by forming bones by acting on bone matrix proteins.
Calcium citrate malate
After administration the drug is absorbed by small intestine in presence of bile salt.
Nearly about 99.8% of the drug is bound to plasma protein.
The elimination half life of drug is 19-48hrs.
It is rapidly absorbed by the intestine with peak serum concentration achieving in 3-6hrs. The serum levels steady state is reaching in 7days with multiple dose administration.
Nearly about 99.9% of the drug is bound to blood. The drug is transported to the blood by alpha-globulin vitamin D binding protein. It involves two pathways for its metabolism i.e 24-hydroxylase catabolism of calcitriol and the second is conversion of calcitriol by stepwise hydroxylation.
The drug follows biliary excretion and excreted in feces.
- Patients with hypercalcemia or evidence of vitamin D toxicity
- Any of the inactive ingredient in the preparation is contraindicated
- Hypersensitivity to any ingredient
- Excessive dosage causes hypercalcemia and in some instances hypercalciuria
- Patient should have normal renal function
- Adequate fluid intake
- Avoid non prescription drugs
- Regular analysis of the patients with such prescription.